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Manisha Singhaa*, Yash Prasharb
aScott Edil Pharmacia Limited Unit-II Baddi, Himachal Pradesh, India
bDepartment of Pharmacology, Rayat Institute of Pharmacy, Railmajra, Distt. SBS. Nagar, Punjab 144533, India
*Address for Corresponding Author
Ms. Manisha Singha
Scott Edil Pharmacia Limited Unit-II, Baddi, Himachal Pradesh, India
Abstract
Background: Scientifically obesity (Corpulence) refers to “excessive accumulation of Body Fat”. Obesity is rapidly increasing across the world at an alarming rate. Various conventional drugs available in the market are associated with copious side effects that can also lead to rebound obesity. Drug interventions based on Natural products prompted as one of the crucial strategies for the treatment and management of obesity. Objective: The current study was designed to investigate the anti-obesity activity of methanolic extract of Inula racemosa, Ceratonia siliqua and its combination on GTG induced obese mice. Method: In-vitro anti-obesity activity of MEIR, MECS and its combination was done on various enzymes such as α Glucosidase, α amylase and pancreatic lipase. Female Albino mice were randomly divided into eleven groups. For the induction of obesity experimental mice were injected with a single i.p. injection of GTG. At the end of the experimental protocol, animals were sacrificed and various anthropometrical, nutritional, biochemical, histopathological parameters and gene expression of PPAR-γ were studied. Results: Supplementation with MEIR, MECS and its combination significantly (p<0.01 & p<0.05) reduced the severity of various anthropometrical, nutritional, biochemical parameters. Histopathological examination revealed the therapeutic effect of both drugs and their combination. Furthermore, at the molecular level MEIR, MECS and its combination remarkably down-regulated the expression of PPAR-γ. Conclusion: Together the results of physical, biochemical, histopathological parameters and molecular study unambiguously demonstrate the anti-obesity activity of MEIR, MECS and its combination, promoting it as an admiring future candidate for the development of gene-specific anti-obesity drugs.
Keywords: Anti-obesity, Inula racemosa, Ceratonia siliqua, pharmacological synergy, In-vitro assays, PPAR-γ, histopathology
