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Manju Kushwaha1, Santram Lodhi2
1Vedica College of B. Pharmacy, Ram Krishna Dharmarth Foundation University, Bhopal (M. P.) 462033
2Sri Sathya Sai Institute of Pharmaceutical Sciences, Ram Krishna Dharmarth Foundation University, Bhopal (M. P.) 462033
*Address for Corresponding author
Dr. Santram Lodhi
Sri Sathya Sai Institute of Pharmaceutical Sciences, Ram Krishna Dharmarth Foundation University, Bhopal (M. P.) 462033
Abstract
Objective: The present study was aimed to investigate the pharmacological potential of Helicteres isora on the central nervous system, as well as antioxidant activity. Methods: Phytochemical study was performed for detection of various chemical constituents in the Helicteres isora roots. The behavioral despair model was performed in order to investigate the ability of Helicteres isora roots in the elevation of suppressed mood, which is quite common in today’s scenario. Results: The phytochemical investigation of plant extracts were showed that it contains variety of phytochemicals specially we found that the ethanolic extract of Helicteres isora roots contain phenolics, flavonoids, glycosides and tannins. The present findings suggested that ethanolic extract when administered at an acute dose of 100 and 200 mg/kg of body weight (P<0.05) reduced the immobility time by 160 and 125 sec, respectively, as compared to the immobility time of control i.e. 180 sec. These results were shown that after standard i.e. Imipramine HCl (100 mg/ml) and the ethanol extract is most potent in dose dependent manner. Findings on tail suspension test were quite comparable to the previous FS test. In both these studies, ethanol extract significantly reduced the immobility time 160 and 125 sec. at a dose of 200 mg/kg and 100 mg/kg respectively, which was comparable to the standard group. Major ingredients reported in the ethanol extract are polyphenols, especially flavonoids including quercetin. Conclusion: In conclusion, Helicteres isora roots are showed potent antidepressant effect through possible antioxidant mechanism. This effect may be due to presence of flavonoid components present in ethanol extract of Helicteres isora roots.
Keywords: Helicteres isora, antidepressant, quercetin, polyphenols, antioxidant
