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Ajay Kumar Garg*1, Ranjan Kumar Singh2, Khushboo Srimali3, Saurabh K. Sinha4, Vivek Jain4
1Department of Pharmaceutical Chemistry, Shekhawati Institute of Pharmacy, Rajasthan, India
2Department of Pharmacology, Shekhawati Institute of Pharmacy, Rajasthan, India
3Department of Pharmaceutical Chemistry, Mahatma Gandhi College of Pharmacy, Rajasthan, India
4Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan-313001, India
Address for Corresponding Author
Ajay Kumar Garg
Department of Pharmaceutical Chemistry,
Shekhawati Institute of Pharmacy, Rajasthan, India
Abstract
Objective: The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. Matearial and Methods: In this project, the synthesis of semicarbazone derivatives was carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semicarbazide, which was directly coupled with ketones. All the synthesized compounds were biologically screened for their anticonvulsant activity by the MES method. Results: Standard error mean was calculated concerning standard and control drug, Phenytoin sodium (25mg/kg.) and DMSO. The synthesized semicarbazone was characterized by using IR Spectroscopy. One another representative molecule compound was characterized using 1H NMR Spectroscopy. Conclusion: It can be concluded that designed semicarbazones were synthesized and characterized successfully. After synthesis of designed semicarbazones compounds were evaluated for anticonvulsant activity. Finally, two compounds have shown better activity in comparison to the other molecules.
Keywords: Semicarbazone, MES, SEM, anticonvulsant activity, IR, NMR spectroscopy
