Review Articles

2021  |  Vol: 6(2)  |  Issue: 2(March-April) | https://doi.org/10.31024/apj.2021.6.2.3

Lupeol: Bioactive triterpenoid act as anti-inflammatory agent

Ritesh Tiwari¹, Ritu Jain¹, Rama Shankar Dubey², Aarti Tiwari³, Ajay Kumar Shukla^3*

¹Department of Pharmaceutical Science, Madhyanchal Professional University, Bhopal, Madhya Pradesh, India

²Mandsaur University, Mandsaur, Madhya Pradesh, India

³Department of Pharmacy, Institute of Technology and Management GIDA, Gorakhpur, Uttar Pradesh, India

*Address for Corresponding authors:

Dr. Ajay Kumar Shukla

Department of Pharmacy, Institute of Technology and Management GIDA, Gorakhpur, Uttar Pradesh, India

Abstract

Since the earliest times, herbs have been used for the treatment of human diseases. One of the chief bioactive compounds is lupeol, a phytosterol, and triterpene. It is widely found in fruit sources and vegetables. Many types of research have been done, and the researchers have reported numerous important pharmacological activities of lupeol. The preclinical studies of lupeol using a variety of in-vitro studies found that lupeol is a very potent bioactive compound. It can be used as an anti-inflammatory, anti-microbial, anti-protozoal, an antiproliferative, anti-invasive, anti-angiogenic cholesterol-lowering agent, and anticancer. It is also using for wound healing, diabetes, cardiovascular disease, kidney disease, and arthritis treatment. This review especially covers all research work regarding anti-inflammatory action and summarized all the mechanism action regarding the anti-inflammatory action of lupeol. The inflammatory preventive prospects of lupeol and represented its potential anti-inflammatory drug targets. Some more research work needs to do and develop specific derivatives that would be the valuable drug anti-inflammatory. The potential derivatives of lupeol reduced the side effects of the marketed drug.

Keywords: Bioactive compounds, lupeol, phytosterol, triterpene, anti-inflammatory