Review Articles

2024  |  Vol: 9(2)  |  Issue: 2 (March-April)) | https://doi.org/10.31024/apj.2024.9.2.2

Antimicrobial efficacy of Quinolines and Naphthyl-substituted 1, 2, 4-Triazoles

Veshnavi Vishwakarma, Lav Kush Kumar Vishwakarma, Prashant Kumar Vinode*

Sagar Institute of Pharmaceutical Science, Sagar (M.P) 470228 India

*Address for Corresponding Author

Prashant Kumar Vinode

Sagar Institute of Pharmaceutical Science, Sagar (M.P) 470228 India

Abstract

The antimicrobial activity of novel quinoline and naphthyl substituted 1,2,4-triazole derivatives has been reported by various researchers on different test microbes. The synthesis involved the preparation of diverse 1,2,4-triazole compounds bearing quinoline and naphthyl moieties through efficient synthetic methodologies. The structural characterization of the synthesized compounds reported using spectroscopic techniques such as 1H NMR, 13C NMR, and FT-IR spectroscopy, confirming the desired molecular structures. Subsequently, the antimicrobial potential of these compounds has been studied against a panel of pathogenic microorganisms including bacteria and fungi using standard agar diffusion and broth microdilution methods. Studied has been confirmed promising antimicrobial activity of several synthesized compounds, with some exhibiting notable inhibition zones and minimal inhibitory concentrations against tested microbial strains. These reported findings suggest the potential of quinoline and naphthyl substituted 1,2,4-triazole derivatives as promising candidates for further development as antimicrobial agents, warranting further investigation into their mechanism of action and pharmacological properties. This review is compile the various new chemical entities with antimicrobial properties, which could address the growing concerns regarding antimicrobial resistance in clinical settings.

Keywords: Antimicrobial activity, Quinoline, Naphthyl, 1,2,4-triazole and Structure-activity relationship