Review Articles

2021  |  Vol: 6(2)  |  Issue: 2(March-April) | https://doi.org/10.31024/apj.2021.6.2.1

Controlled drug release rate and contemporary issues in oral drug delivery formulations

Ritu Jain¹, Ritesh Tiwari¹, Rama Shankar Dubey², Aarti Tiwari³, Ajay Kumar Shukla³

¹Department of Pharmaceutical Sciences, Madhyanchal Professional University, Bhopal,

Madhya Pradesh, India

²Department of Pharmaceutical Sciences, Mandsaur University, Mandsaur, Madhya

Pradesh, India

³Department of Pharmacy, Institute of Technology and Management GIDA, Gorakhpur,

Uttar Pradesh, India

Corresponding authors

Dr. Ajay Kumar Shukla

Department of Pharmacy, Institute of Technology and Management GIDA, Gorakhpur,

Uttar Pradesh, India

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Abstract

Principles of controlled drug delivery are the release of the drug in a controlled manner for prolong period. These types of dosage forms need were to maintain the drug concentration for a long period. The treatment of disease states has traditionally involved the use of multiple daily dosing of a therapeutic agent using a conventional dosage form, e.g., tablets. The development of such systems is the role of pharmaceutical polymers. In light of the current and continuing importance of this category of drug delivery system, the following section provides a concise overview of the range of designs of controlled release drug delivery systems. The controlled or sustained drug delivery systems, required the drug is homogeneously dispersed, either at the molecular scale or as solid particles, within a carrier system. The most usual using oral dosage form, like matrix tablets therefore in this review we are discussed matrix tablets. The matrix tablet formulations are affected by various factors that affected the release rate of drugs through the oral drug delivery Systems. This information can be very valuable for the development of such type of formulation.

Keywords: Controlled drug delivery, sustained release, polymers, matrix tablets