Review Articles

2018  |  Vol: 3(5)  |  Issue: 3 (September- October) | https://doi.org/10.31024/apj.2018.3.5.1
Vitamin C: Properties, function and application in cancer therapy

Satish Shilpi1*, Roshni Shivvedi1, Amrita Singh1, Gaurav K. Saraogi2, Vikas Jain, Kapil Khatri1

1Drug Targeting Research Project Laboratory, Department of Pharmaceutics, Ravishankar College of Pharmacy, Bhopal, India

2NMIMS, School of Pharmacy and Technology Management, Shirpur, India

3JSS College of Pharmacy, Mysuru, Karnataka, India

*Address for Corresponding Author:

Dr. Satish Shilpi,

Drug Targeting Research Project Laboratory

Ravishankar College of Pharmacy, Bypass Road, Bhanpur Square, Bhopal (MP), India

Abstract

Vitamin-C or ascorbic acid is an excellent chain breaking type of antioxidant occupied in many biological processes in the body. It is a cofactor for the different type of metabolic enzymes. Vitamin-C has different properties such as anti-aging, anti scurvy, antiviral and antibacterial, enhancing immunity, involved in detoxification process. It has the ability to inhibit cancer cell proliferation by enhancing the immune system, stimulation of collagen synthesis, inhibiting the hyaluronidase and generate reactive oxygen or increased levels of H2O2, induction of apoptosis which damaged the tumor cells but and it does not give the cytotoxic effect to the normal cell. Its anticancer effect is dose-dependent. In this review, highlight the properties, applications and beneficial effects of ascorbate in cancer therapy and its prevention and its potential antitumor effects.

Keyword: Ascorbic acid, anticancer, immunity enhancer, collagen

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