Research Articles

2019  |  Vol: 4(3)  |  Issue: 3 (May- June) | https://doi.org/10.31024/apj.2019.4.3.3
In-vivo anticancer activity of Curcumin-Hyaluronic acid conjugate

Manjunatha P. Mudagal*, Suresh Janadri, Nageena Taj

Department of Pharmacology,

Acharya and B.M. Reddy College of Pharmacy, Soldevanhalli, Acharya Dr. Sarvepalli Radhakrishna Road, Bengaluru-560090, Karnataka, India

*Address for Corresponding Author

Dr. Manjunatha P. Mudagal

Department of Pharmacology,

Acharya and B.M. Reddy College of Pharmacy, Soldevanhalli, Acharya Dr. Sarvepalli Radhakrishna Road, Bengaluru-560090, Karnataka, India

Abstract

Objective: Polymer-drug conjugates have gained much attention largely to curcumin lower drug solubility and to enhance drug stability. Curcumin is widely known for its medicinal properties including its anticancer efficacy. One of the serious drawbacks of curcumin is its poor water solubility which leads to reduced bioavailability. Materials and methods: Curcumin – HA conjugate was assessed for anticancer activity in EAC induced mice. And haematological parameters, differential count, body weight changes and mean survival time was assessed. Results: The results showed Conjugate (HA–Cur) produced extremely significant as anticancer activity by change in haematological parameters, differential count, body weight changes and mean survival time. Conclusion: Conjugated curcumin also showed potential anticancer activity.

Keywords: Curcumin, conjugate, anticancer, hyaluronic acid (HA)

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