Review Article

2018  |  Vol: 3(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2018.3.4.4
Role of Lupeol as potent inhibitor for the management of inflammatory disorders

Pallav Namdeo, Ashish Garg*

Department of P.G. Studies and Research in Chemistry and Pharmacy, Rani Durgavati University, Jabalpur, M.P.482001, India

*Address for Corresponding Author

Mr. Ashish Garg

Department of P.G. Studies and Research in Chemistry and Pharmacy

Rani Durgavati University, Jabalpur, M.P.482001, India

Abstract

Triterpenes are a wide-spread group of secondary metabolites with considerable biological significance. Triterpenes are important structural components of plant membranes, and free triterpenes serve to stabilize phospholipid bilayers in plant cell membranes just as cholesterol does in animal cell membranes. Many triterpenes are present as natural components of human diets. Lupeol is a triterpene mainly found in olive, mango, white cabbage, green pepper, strawberry, and grapes. It has been reported to possess many beneficial effects as a therapeutic and preventive agent for many disorders. Lupeol exhibits potential benefits in certain inflammatory diseases like arthritis, colitis both in in vitro and in vivo studies. Many researchers worldwide worked on this molecule to develop a potent agent for its clinical use for the treatment of many disorders like cancer and many more. These studies also provide insight into the mechanism of action of Lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B (NFκB) and phosphatidylinositol-3-kinase in a variety of cells. This review consists of detail properties, their mechanism, and reported biological activities for inflammatory disorders.

Keywords: Lupeol, triterpene, arthritis, inflammatory, cancer

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