Research Articles

2018  |  Vol: 3(5)  |  Issue: 3 (September- October) | https://doi.org/10.31024/apj.2018.3.5.4
Study on wound healing effect of Milk Bush (Euphorbia tirucalli Linn) in albino mice

Criselda T. Gorda1, Abel Alejandro U. Flores Jr.1,2*

1Department of Biological Sciences, College of Science

University of Eastern Philippines, University Town, Northern Samar, Philippines 6400

2University Research and Development Services,

University of Eastern Philippines, University Town, Northern Samar, Philippines 6400

*Address for Corresponding author

Abel Alejandro U. Flores Jr.

University Research and Development Services,

University of Eastern Philippines, University Town, Northern Samar, Philippines 6400

Abstract

Objective: This study aimed to determine the wound healing effect of Euphorbia tirucalli Linn. latex on albino mice. Material and methods: Phytochemical screening and wound-healing effect of milk bush was done. Test for alkaloids, saponin, anthraquinone, tannins, and steroids were done to profile the phytochemical screening of milk bush. In wound-healing, betadine was used as the positive control. Albino mice were evaluated if the efficacy of milk bush as wound-healing is greater than the commercial product. Results and conclusion: Examination of the physical properties of E. tirucalli Linn. showed it has a white color, with an unpleasant odor, a density of 2.6233 g/mL, a pH of 5.92, which is acidic, and was miscible in water, while immiscible in hexane and acetone. As for its chemical properties, it was positive in alkaloids, flavonoids, and steroids, but was negative in tannin, saponin, and antraquinone. The pure latex of the plant showed positive wound healing effect as manifested by the formation of scar tissue which effectively led to wound closure and eventual healing after six days of observation.  Based on the analysis of variance, there was a significant difference that exists between and among the different concentration levels of E. tirucalli L. latex and the commercial antiseptic “Betadine”. Impliedly, the plant latex is not comparable with the commercial preparation. However, the researchers believe, as borne out by the results, that the latex was effective in healing wounds and skin lacerations. The researchers recommend further studies using other part of E. tirucalli L. to determine its potential medicinal applications, in-depth characterization of the phytochemicals present in the latex of E. tirucalli L., and the use of the plant latex as a first aid application for wounds and lacerations should be studied further, considering that the substance is reputed to be poisonous.

Keywords: Wound healing effect, antiseptic, milk bush, albino mice

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