Research Articles

2018  |  Vol: 3(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2018.3.4.3
Evaluation of antidepressant activity of aqueous extract of Prosopis cineraria leaves by using tail suspension test in Swiss albino mice

Parigala Madhavi, B. L. Kudagi*,  Madhavulu Buchineni, Rama Mohan Pathapati

Post graduate,  Head  of  the  department,  Professors

Department of  Pharmacology, Narayana Medical College, Nellore, Andhrapradesh, India.

*Address for Corresponding author

Dr. B. L. Kudagi, 

HOD, Department of Pharmacology, 

Narayana Medical College, Nellore, Andhrapradesh, India, 524003 

Abstract

Objectives: To evaluate antidepressant activity of aqueous extract of Prosopis cineraria leaves by using Tail suspension test in Swiss albino mice. Materials and Methods: 24 Swiss albino mice of  6-8wks old  weighing  in  the  range of  20 to 25gms  were selected for  the study  and administered  the drugs, viz  Control- normal saline( 2ml/kg) oral , Standard- amitriptyline (10mg/kg) oral, and  Test  drug Prosopis cineraria (100 & 200mg/kg) oral . All  the  drugs  were administered , screened  for antidepressant activity at  0, 20, 60, 90 min by suspending  them  from a rod 50cm above  the ground level and  duration of  immobility time was recorded  over a period of  six minutes (discarding initial two minutes to avoid bias). Results: Prosopis cineraria  at 100 & 200 mg/kg  has shown significant antidepressant activity with decrease in duration of  immobility with 97.00  ± 2.30 & 94 ± 3.23 sec at 90min with a p value of <0.0001 respectively. Conclusion: In our study, we identified the potent and efficacious antidepressant activity of   aqueous extract of leaves of Prosopis cineraria.

Keywords:  Antidepressant, Prosopis cineraria, Tail suspension test

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