Research Articles

2019  |  Vol: 4(2)  |  Issue: 2(March-April) | https://doi.org/10.31024/apj.2019.4.2.3
Assessment of anthelmintic and in vitro H +-K + ATPase inhibitory potential of hydroalcohalic extract of Achyranthes aspera Linn.

Gopal Rai1, Pramod Maurya1, Pushpendra Kumar Jain2, Ajay Kumar Shukla1

1Department of Pharmaceutical Science, Guru Ram Das Khalsa Institute of Science & Technology Pharmacy, Jabalpur (M. P.), India

2IIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India

Abstract

Objective: Objective of this work was to evaluate the in vitro anthelmintic and H + -K + ATPase inhibitory possible of Hydroalcohalic (70:30) extract of Achyranthes aspera Linn. aerial part. Materials and Methods: The total flavonoid content, phenol content, anthelmintic activity, H + -K + ATPase inhibition assay was performed in presence of different concentrations of Hydroalcohalic (70:30) extract. Results: The Hydroalcohalic (70:30) extract of Achyranthes aspera Linn showed considerable (*P < 0.05) anthelmintic and proton pump inhibitory activity in the goat gastric mucosal homogenate which was equivalent to standard. Conclusions: The activities were found to be dose dependent and this study indicates that Hydroalcohalic (70:30) extract of Achyranthes aspera were found to suppress sheep mucosal H+K+ ATPase activity in-vitro. So, further study is needed to confirm the gastro protective property of Achyranthes aspera aerial part.

KeywordsAchyranthes aspera Linn, H+ K+ ATPase inhibition, anthelmintic, Folin-Ciocalteau, Albendazole

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