Review Articles

2021  |  Vol: 6(2)  |  Issue: 2(March-April) | | https://doi.org/10.31024/apj.2021.6.2.2
Role of Click Chemistry in development of Biomedicines

Shailee V Tiwari*, Mohammad Zishan Ibrahim

Department of Pharmaceutical Chemistry, Durgamata Institute of Pharmacy, Dharmapuri, Parbhani, MS, India (431401)

*Address for Corresponding Author

Shailee V Tiwari

Department of Pharmaceutical Chemistry, Durgamata Institute of Pharmacy, Dharmapuri, Parbhani, MS, India (431401)

Abstract

The important purpose of medicinal chemistry is to incorporate compounds or study of compounds during the process of drug discovery or lead optimization. The recognition of these rapid synthetic methodologies should permitting the medicinal chemist to arrange a large amount of biologically active compounds in a very short period of time which facilitate the process of drug discovery and lead optimization. Click chemistry involved a set of reactions that are fast, simple, regiospecific, easy to purify, versatile, and give high product yields. Most of the reactions that fulfill the criteria are discussed, the Huisgen 1, 3-dipolar cycloaddition of azides and terminal alkynes has appear as a front-runner. It has number of applications in various fields of research areas, including pharmaceutical sciences, materials sciences, polymer chemistry. In this article, important aspects of the Click reactions are been reviewed, along with some of its applications in biomedicine. Bio conjugation, nanoparticle Polymer and pharmaceutical-related polymer chemistry is also been covered. Types, advantages and limitations of Click reaction are also beenenclosed in this article.

Keywords: Click Chemistry, biomedicines, medicinal chemistry, bio-conjugation

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