Review Articles

2023  |  Vol: 8(6)  |  Issue: 6(Nov-Dec) | https://doi.org/10.31024/apj.2023.8.6.3

Role of Indian herbal medicines and Nitro Imidazole derivatives in the management of ulcer

Vineeta Devi Shivhare, Prashant Vinode*

Sagar Institute of Pharmaceutical Science (SIPS), Sagar, (M.P.), India

*Address for Corresponding Author

Prashant Vinode

Sagar Institute of Pharmaceutical Science (SIPS), Sagar, (M.P.), India

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Abstract

Ulcer is a common gastrointestinal disorder, which is widely occurring among the human beings. Ulceration generates when there is impairment of the normal equilibrium caused by either enhanced aggression or reduced mucosal resistance. Peptic ulcer is a broad term that imparts ulcer of digestive tract in the stomach or duodenum. Varieties of natural and synthetic drugs are available for the management and treatment of ulcer. At present scenario, nitroimidazole is found most multifaceted heterocyclic ring having as it has numerous therapeutic and medicinal properties. Nitroimidazole and its several derivatives possess significant antiulcer activity, antimicrobial activity, antiviral activity, anticancer activity, analgesic activity. In this review article there have been emphasized on the treatment of ulcer with the help of nitroimidazole and its derivatives and application of various herbal medicines. Imidazole is a five membered, heterocyclic ring, which contains two hetero (nitrogen) atoms and two double bonds. There are so many compounds which contain Imidazole ring and exhibit different types of pharmacological and biological activities like metronidazole and nitroimidazole as bactericidal, 1-vinyl imidazole as fungicidal, megazol as trypanocidal, imidazole-2-one as antileishmanial and other antimicrobial activities.

Keywords: Peptic ulcer, H. pylori, Anti-Helicobacter pylori, Nitroimidazole, herbal medicines