Tilotma Sahu*, Abhishek kumar, Chanchal Deep Kaur
Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari,Durg, Chhattisgarh, India
*Address for Corresponding Author
Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India
Objective: The objective of the study was to increase the bioavailability of drug by preparing complex of Sertraline HCl with ghee. Materials and methods: Dissolution study was done by using paddle apparatus USP type 2 and permeation studies were performed by everted intestinal method. The different ratios of complexes were prepared by solvent evaporation method and evaluated. The complexes of Sertraline HCl: native ghee complex (1:1 to 1:5). Results: The permeation of pure drug was found to be 86% at 1 hour. In complex ratio drug: ghee 1:1, it showed 42.55% drug permeation at 15 minutes,78.14% at 45 minutes. In 1:2 (drug: ghee complex) it shows 46.93% drug permeation at 15 minutes, 85.53 % at 45 minutes. In drug: ghee (1:3) % drug permeation at 15 minutes it was 50.26% and increases to 92.23% at 45 minutes. In complex 1:4(drug :ghee) at 15 minutes the % drug release was 55.41% and increasingly it goes to 95.22 % at 45 minutes .In drug: ghee (1:5) % drug release at 15 minutes it was 60.12% and 98.25% at 45 minutes. In drug: oxidized ghee (1:1) the % drug permeation was 40.83% at 15 minutes which increases to 76.25% at 45 minutes. In drug: ghee (1:2) 42.58% drug permeates at 15 minutes, 89.88% at 45 minutes. Again by increasing the amount of ghee in ratio (1:3) it gives 48.95% release at 15 minutes than 90.15 at 45 minutes, in (1:5) drug: ghee complex shows 59.87% at 15 minutes and at 45minutes the drug complex permeates 96.16% drug. Thus the prepared complexes effectively increased the drug permeation. In dissolution study of Sertraline HCl, the percent drug release of pure Sertraline HCl was 35.83 % at 15 minutes and 48.29% at 45 minutes. Again in complex ratios of 1:1 to 1:5 at 15 minutes was 25.09%,19.23%14.55%10.89% and 6.95% respectively, at 45 minutes the percent drug release of drug: ghee complex1:1 to 1:5 was found to be 46.25%,39.88%31.89%,25.78%,21.99% drug release respectively. Conclusion: From the above studies we found that increasing the amount of ghee in complexes there is decrease in dissolution of drugs and increasing in permeation. Thus the prepared complexes effectively increased the drug permeation.
Keywords: Permeation, dissolution, ghee, bioavailability, Sertraline