Salihu J. U.1*, M. Yushau2, L. D. Fagwalawa3, A. A. Shehu1
1Department of Microbiology, Kano University of Science and Technology, Wudil, P.M.B. 3244, Kano State-Nigeria
2Department of Microbiology, Bayero University P.M.B. 3011, Kano-Nigeria
3Department of Biological Sciences, Kano University of Science and Technology, Wudil, P.M.B. 3244, Kano State-Nigeria
*Address for Corresponding Author
Salihu J. U.
Department of Microbiology,
Kano University of Science and Technology, Wudil, P.M.B. 3244, Kano State-Nigeria
Abstract
Objective: The study was aimed at determination of the resistance profile of bacterial isolates associated with urinary tract infection from patients attending general hospital Dawakin-Kudu, Kano State-Nigeria. Methods: A total of 85 bacterial isolates from urinary tract infection including; Escherichia coli (42 isolates), Pseudomonas aeruginosa (14 isolates), Klebsiella pneumoniae (12 isolates), Proteus mirabilis (7 isolates), Staphylococcus aureus (6 isolates) and Staphylococcus saprophyticus (4 isolates) were subjected to antimicrobial susceptibility testing according to Clinical Laboratory Standard Institute (CLSI) guidelines using standard discs of Imipenem (10mg), Meropenem (10mg), Nitrofurantoin (200mg), Tetracycline (30mg) and Erythromycin (15mg). Results: The result showed high sensitivity of isolates to Imipenem (100%), Meropenem (100%), Nitrofurantoin (83.33%), Tetracycline (100%) and Erythromycin (75%). On the other hand, high degree of resistivity rates to Ampicillin (100%), Co-trimoxazole (85.71%), and Cephalexin (100%) were detected. The bacterial isolates showed varied degree of multidrug resistance (MDR). Bacterial isolates that produced ESBL were more resistant to Ceftazidime, and Ceftriaxone compared to non-ESBL producers. Multidrug resistance strains were also tested for extended spectrum beta lactamase (ESBL), 29(58%) of the isolates were ESBL producers. According to this study, most of predominant species enumerated in this community was highly sensitive to Imipenem, Meropenem, Tetracycline, Erythromycin and Nitrofurantoin respectively and are recommended as antibiotics of choice against the pathogens. On the other hand, the increasing prevalence of bacterial resistance to commonly used antibiotics has made susceptibility testing a crucial aspect in the treatment of serious bacterial infections. Conclusion: Therefore, there is need for government to increase surveillance of ESBL-producing organisms as they pose serious threat to successful treatment of infections in this community and exacerbates the problem of antimicrobial resistance in the hospitals, especially in resource poor Community settings.
Keywords: Antibiotics, resistance profile, bacterial isolates, urinary tract infections, ESBLs
