Research Articles

2019  |  Vol: 4(1)  |  Issue: 1(January-February) | https://doi.org/10.31024/apj.2019.4.1.4
Formulation development and evaluation of Transferosomal drug delivery for effective treatment of acne

Jay Prakash Sahu1, Anwar Iqbal Khan1, Rahul Maurya2, Ajay Kumar Shukla3*

1NRI Institute of Pharmacy, Bhopal (M.P.) India

2Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) India

3Guru Ramdas Khalsa Institute of Science and Technology Pharmacy, Bhopal (M.P.) India

*Address for Corresponding Author

Ajay Kumar Shukla

Guru Ramdas Khalsa Institute of Science and Technology Pharmacy, Bhopal (M.P.) India

Abstract

Objective: The objective of the present work was to formulation, development and evaluation of transferosomal drug delivery for effective treatment of acne. Materials and Methods: Soya phosphatidyl choline, sodium cholate, Tazarotene, ethanol and all chemicals and reagents used were of analytical grade. Results: Different formulation (F-1 to F-8) of transfersomes were prepared and eveluated for vesicle size and entrapment efficiency. The vesicle size of all transfersomes varied between 155.2 and 262.1nm where as entrapment efficiency was found between 60.12 to 75.65%. Results showed that in formulation F4 which contain smallest vesicle size and increase in entrapment efficiency, Formulation F4 selected as optimized formulation and further incorporated into gel base (TF1, TF2, TF4) and evaluated for Drug content, pH, Spreadibility, Viscosity measurements and In-vitro drug release study. Transfersomes gel released drug in controlled release manner in 12 hour but in case of marketed formulation there is no controlled release of drug from gel. Conclusion: The developed of Tazarotene as transfersomal gel has the ability to overcome the barrier properties of the skin and increase the drug release

Keyword: Acne vulgaris, transfersomes, tazarotene, development, evaluation, topical

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