Research Articles

2018  |  Vol: 3(2)  |  Issue: 2(March-April) | https://doi.org/10.31024/apj.2018.3.2.3
Evaluation of Antioxidant activity of Cardiospermum halicacabum Linn leaves in Atherodiet induced hyperlipidemic wistar albino rats

1*Thamizh Selvam N., 2Surabhi K.R., 3Sanjaya Kumar Y.R., 4Vasantha Kumar K.G., 5Sudesh Gaidhani N., 6Radhakrishnan P.

1Assistant Director-Biochemistry, Department of Biochemistry and Pathology, National Ayurveda Research Institute for Panchakarma, Cheruthuruthy.

2Senior Research Fellow, Department of Biochemistry and Pathology, NARIP, Cheruthuruthy

3Assistant Director- Pharmacology, Department of Pharmacology, NARIP, Cheruthuruthy

4Assistant Director- Chemistry, Department of Chemistry, NARIP Cheruthuruthy

5Assistant Director-Pharmacology, Programme Officer, Central Council for Research in Ayurvedic Sciences, New Delhi

6Assistant Director In-Charge, Head of the Institution, NARIP, Cheruthuruthy.

*Address for corresponding author

Dr. N. Thamizh Selvam Ph.D.,

Assistant Director- Biochemistry

National Ayurveda Research Institute for Panchakarma

(CCRAS, Ministry of AYUSH, Govt. of India)

Cheruthuruthy , Kerala- 679 531 India.

Abstract

Objective: Cardiospermum halicacabum Linn commonly known as ‘Balloon vine’ is a climber found in Western ghat region.  The plant is claimed for medicinal properties and used by traditional healers of Kerala for treatment of various ailments.  The present study has evaluated the antioxidant potential of C. halicacabum Linn Leaf in the atherodiet induced hyperlipidemic wistar albino rats. Materials and methods: The study comprised of six groups such as control group, test extract group, disease control group, treatment group low dose, treatment group high dose and standard drug group.  The duration of the study was 28 days and the extract was administered in the animals as per the standard protocol.  The antioxidant parameters such as Superoxide dismutase, Catalase, Glutathione and Glutathione peroxidise were evaluated in the blood and tissue samples of liver, kidney and heart. Results and conclusion: The study evidenced that the C. halicacabum leaf has significant antioxidant potential in blood and tissue level when compared with different groups. 

Keywords: Cardiospermum halicacabum, antioxidant activity, hyperlipidemia, SOD, catalase

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