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Virendra Ahirwar, Saumya Jain*, Parveen Nisha
Sagar Institute of Pharmaceutical Sciences, Sagar (M.P.) 470228, India
*Address for Corresponding Author
Saumya Jain
Sagar Institute of Pharmaceutical Sciences, Sagar (M.P.) 470228
Abstract
The liver is the body's largest and most essential organ, involved in the metabolism to food and medications. Humans are at risk to dying from liver illnesses. During drug development, pre-clinical research, and clinical treatment, liver damage is a significant reason to drug approval withdrawal. Patients with significant liver injury may have abrupt liver failure or possibly death if not appropriately treated. A deeper knowledge to primary mechanisms is required for the development to new therapeutic medicines. As a result, animal models that mirror human liver illnesses are being produced. For decades, animal models have been utilised to research the pathophysiology to liver illnesses and related toxicity. Various animal models were revealed in this review. Our primary goal is to investigate all new and conventional animal models that are classified as non-invasive and generate hepatotoxicity.
Keywords: Liver, hepatotoxicity, animal model, therapeutic medicines, injury, non-invasive
