Research Articles

2020  |  Vol: 5(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2020.5.4.3

Preparation and characterization of floating tablet of Losartan Potassium for gastric retention improvement

Aman Tiwari *, Anjana Bharadwaj

RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India

*Address for Corresponding Author

Aman Tiwari

RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India

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Abstract
Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release. Material and methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and sodium bicarbonate, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression parameters known as the angle of repose, bulk density, tapped density, Hausner’s ratio, compressibility index, and post-compression parameters are uniformity of weight, hardness, and drug content percentage, and Fourier transform infrared spectroscopy (FTIR). Results: An in vitro dissolution study was carried out by using buffer pH 1.2. From in vitro dissolution studies, it has been found that an increase in polymer concentration diminishes the drug release profile. Conclusion: Tablets containing HPMC K4M (20.00%, w/w), Ethyl cellulose (8.0%, w/w) and NaHCO₃ (10%, w/w) (formula F9) showed satisfactory results  with respect to floating lag time, total floating duration, swelling ability, and controlled drug release rates.

Keywords: Losartan potassium, HPMC K4M, guar gum, and direct compression technique, floating drug delivery systems (FDDS)