Kahina Benfattoum1*, Nabila Haddadine1*, Khaled Beyaz1, Naima Bouslah1, Ahmed Benaboura1, Philippe Maincent2, Régis Barillé3, Anne Sapin-Minet2
1Laboratoire de Synthèse Macromoléculaire et Thio organique Macromoléculaire, Université des Sciences et de la Technologie Houari Boumediene, Faculté de chimie, B.P. 32, El Alia, Bab Ezzouar, Alger, 16111, Algérie.
2 Université de Lorraine, CITHEFOR EA3452, Faculté de Pharmacie, Nancy, France
3Laboratoire MOLTECH ANJOU, Université d’Angers/UMR CNRS 62002, Bd Lavoisier, 49045 Angers, France.
*Address for Corresponding Author
Prof. Nabila Haddadine
Laboratoire de Synthèse Macromoléculaire et Thio organique Macromoléculaire,
Université des Sciences et de la Technologie Houari Boumediene, Faculté de chimie, B.P. 32, El Alia, Bab Ezzouar, Alger, 16111, Algérie.
Objective: Novel beads formulations based on, dextran and sodium alginate biopolymer were prepared and evaluated for in vitro sodium diclofenac (SD) release. Material and methods: Dextran-calcium alginate (Dex-CA) beads, loaded SD were prepared by the ionotropic gelation method using calcium chloride as a cross-linker agent. The effects of biopolymer-blend ratio and the concentration of the cross-linker on the cumulative drug release after 8h (R8h%) and the drug encapsulation efficiency (DEE%), were monitored using the response surface methodology (RSM) based on 32 factorial design. Results and conclusion: The results showed that particle beads formed under optimal conditions presents a DEE value of 66.94±2.45 %, R8h of 61.14±2.32 %, mean diameter of 1.08±0.01 mm and density of 2.73±0.31 g/cm3. Additionally, the beads were unaffected in acidic gastric pH; however, they showed a swelling behavior under alkaline intestinal pH. The in vitro drug release from the beads followed the (Hixson-Crowell), equation monitoring the super case-II transport mechanism, related to the swelling and the relaxation behavior of the polymeric matrix. Moreover, the important drug encapsulation efficiency and the sustainable drug release of these materials make them promising for the development of novel drug carrier systems.
Keywords: Polysaccharide, beads particles, statistical optimization, drug delivery carriers