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Manisha Singha*, Sumit Kumar
Scott Edil Pharmacia Limited Unit-II Baddi, Himachal Pradesh, India
*Address for Corresponding Author
Ms. ManishaSingha
Scott Edil Pharmacia Limited Unit-II, Baddi, Himachal Pradesh
Abstract
Background: Obesity is a lifestyle related disorder that is rapidly increasing day by day due to fast-paced life. Many treatments available in the market claim to treat obesity, but comes with masses of side effects. That’s why people are getting attracted by Ayurveda and Ayurvedic medicinal approaches for the treatment of obesity. Objective: The current study aimed to formulate herbal tablets of Inula racemosa and Ceratonia siliqua plant extracts by performing all the possible pre-formulation studies required in the development process. Material and methods: Various pre-formulation studies like organoleptic properties, bulk characterization, physiochemical investigation, phyto-chemical investigations etc were performed. Excipient compatibility study in solid state in ratio a 1:1 was also performed prior to formulation development. Results and conclusion: A regular 2-level factorial design (2FI) with three center points was applied for the formulation optimization design of poly-herbal tablet. The stability study for poly herbal tablets of Inula racemosa and Ceratonia siliqua were performed and the formulation found stable after three months at accelerated conditions. Formulation F5 showed best result among all other formulations that were reproduced as formulation F6 and F7. The performed stability study also showed that the formulation is stable at 40°C temperature and 75%RH for 3 months. The whole study gives a brief idea and a support structure for developing Inula racemosa and Ceratonia siliqua plant extract tablets.
Keywords: Inula racemosa, Ceratonia siliqua, Pre-formulation Studies, DOE, Stability studies
