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Characteristics, transmission and pathogenesis of human Polyomavirus: A Review Advance Pharmaceutical Journal

Review Articles

2021  |  Vol: 6(5)  |  Issue: 5 (September- October) | https://doi.org/10.31024/apj.2021.6.5.3
Characteristics, transmission and pathogenesis of human Polyomavirus: A Review

Mohammad Ameen Mohammad Mahmood, Mohammad Zishan Ibrahim, Shailee V. Tiwari*

Department of Pharmaceutical Chemistry, Durgamata Institute of Pharmacy, Dharmapuri, Parbhani, MS, India 431401

*Address for Corresponding Author

Shailee V. Tiwari*

Department of Pharmaceutical Chemistry, Durgamata Institute of Pharmacy, Dharmapuri, Parbhani, MS, India 431401

Abstract

The family Polyomaviridae contain about a number of human polyomaviruses (HPyVs), of which JCV, MCPyV, SV-40 and BKV viruses have been reported to cause many types of cancer in human. Merkel cell carcinoma is a very antagonistic type of skin cancer caused by the MCPyV5. Similarly, while JCV and SV-40 viruses developed brain tumour cancer, the BK virus has been bind to renal transplantations, prostate cancer and nephropathy producing urinary bladder tumor in human. The name of the family Polyomaviridae, derives from the observation that cells infected with murine polyomavirus produced multiple(poly) tumor (omas) in immune compromised mice. Although, present proof only supports to the role of MCPyV as a carcinogen in to the humans. In the present review we present a summarized discussion on the current knowledge regarding the role of JCPyV, TSPyV, BKPyV and MCPyV in human cancers.

Keywords: Polyomavirus, carcinoma, polyomaviridae, popovav

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