Research Articles

2020  |  Vol: 5(6)  |  Issue: 6 (November-December) | https://doi.org/10.31024/apj.2020.5.6.1
Antibacterial activity of Cannabis sativa extracts against Salmonella Gallinarum isolated from Poultry

Yunusa Umar Abubakar1*, Dalha Wada Taura2, Abdulhamed Baba Njobdi2, Patience O. Ihedigbo1, Miracle Uwa Livinus3

1Department of Animal Health, College of Agriculture, Jalingo, Taraba State, Nigeria

2Department of Microbiology, Bayero University, Kano, Nigeria

3Department of Biochemistry, Bayero University, Kano, Nigeria

*Address for Corresponding Author

Yunusa Umar Abubakar

Department of Animal Health, College of Agriculture, Jalingo, Taraba State, Nigeria

 


Abstra​ct

 

Background: Salmonella Gallinarum is a non-motile gram-negative rod and host-specific bacteria for poultry with very high economic implications. Objective: This study was carried out to determine the antibacterial activities of Cannabis sativa plant extracts (petroleum ether and methanolic, seed and leave extracts) against Salmonella Gallinarum isolated from poultry. Materials and Methods: The antibacterial activity of the plant extracts was conducted by assessing the activity of the plant extracts on Salmonella Gallinarum isolated from poultry (chickens) using agar well diffusion method. Results: The antibacterial activity of C. sativa plant extracts against Salmonella Gallinarum ranged between 8.50±0.71 and 23.50±0.71mm. Petroleum ether seed extract had the highest antibacterial activity of 23.50±0.71mm at 2000µg/ml. The antibacterial activities of C. sativa plant extracts were in the order; PSE > PLE > MSE > MLE. All plant extracts inhibited the activities of Salmonella Gallinarum at varying concentration. The minimum inhibitory concentration (MIC) of petroleum ether leave and methanol seed and leave extracts were 125µg/ml respectively while the MIC of petroleum ether seed extract was the least at 62.50µg/ml. The findings show significant antibacterial activity of C. sativa plant extracts against Salmonella Gallinarum (P<0.05). Conclusion: The findings of the present study shows that C. sativa seed and leave extracts can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities that brings about breakthrough in the treatment of Fowl typhoid (FT) caused by Salmonella Gallinarum.

Keywords: Antibacterial, Cannabis sativa, poultry, Salmonella Gallinarum

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