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Godwin Ndarake Enin1, Victor Friday Inyang1, Imaobong Ekwere Daniel1, Jude Efiom Okokon2, Godwin Adakole Ujah3, Itoro Nyakno Willie4, Ikopima Archibong Brown1
1Department of Chemistry, Faculty of Science, University of Uyo, Uyo, Nigeria.
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3Department of Physiology, Faculty of Medicine, University of Calabar, Calabar, Nigeria
4Department of Chemistry, Faculty of Physical Sciences, Akwa Ibom State University Ikot Akpaden, Nigeria
*Address for Correspondence
Godwin Ndarake Enin
Department of Chemistry,
Faculty of Science, University of Uyo, Uyo, Nigeria
Abstract
Objective: Heterotis rotundifolia (Sm.) Jacq. Fel used traditionally by the Ibibio people of Southern Nigeria for the treatment of pain, stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer activity. Materials and Methods: In this study, the effects of the extract (300-900 mg/kg) and different fractions [n-hexane (HEX), ethyl acetate (EAC), methanol (MET) and aqueous (AQU), 600 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin and histamine –induced ulcer models. Results: The extract (300-900 mg/kg) inhibited ethanol, indomethacin and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effect of the extract and the different fractions were comparable to that of the standard drugs used, the MET fraction having the highest activity. GC-MS analysis of the MET extract revealed the presence of polyunsaturated fatty acids such as tridecanoic acid-12-methyl ester, cis-5,8,11,14,17-Eicosapentaenoic acid, octadecanoic acid methyl ester, tetracosanoic acid, 9,12-Octadecadienoic acid (Z,Z)-, and hexadecanoic acid ethyl ester. Conclusion: Thus, H. rotundifolia demonstrated a good antiulcer activity which supports the use of this plant among the Ibibio people of Southern Nigeria ethnopharmacology for ulcer treatment.
Keywords: Antiulcer, Heterotis rotundifolia, phytochemistry, gastroprotective, polyunsaturated
