Research Articles

2019  |  Vol: 4(5)  |  Issue: 5 (September- October) | https://doi.org/10.31024/apj.2019.4.5.1
Phytochemical analysis and HPLC estimation of phytoconstituents of Buchanania lanzan Spreng

Jyoti Shrivastava*, T. Ratna Madhuri

Department of Pharmaceutical Chemistry,

The Oxford College of Pharmacy, Hongasandra, Bangalore-560068, Tamil Nadu, India

*Address for Correspondence

Dr. Jyoti Shrivastava,

The Oxford College of Pharmacy, Hongasandra, Bangalore-560068, Tamil Nadu, India

 

Abstract

Objective: The present study was designed to investigate cytotoxic active principles from crude extract of Buchanania lanzan Spreng based on its ethnobotanical information. The objectives of study are; collection of plant material, extraction and preliminary phytochemical evaluation and preformation of HPLC finger printing of extracts. Materials and methods: The bark of Buchanania lanzan Spreng was extracted with different solvents by soxhlet method and screened for the presence of its phytochemical composition. The ethanolic and ethyl acetate extracts were selected due to its high percentage yield for HPLC fingerprinting. Results: The bark of Buchanania lanzan Spreng showed the presence carbohydrates, alkaloids, flavonoids, saponins, proteins, amino acids and phenolic compounds. The comparative study of total flavanoid content and total phenolic content of ethanolic and ethyl acetate extracts shows that ethyl extracts had higher content of galic acid and quercetin as compared to ethanolic extract. Conclusion: Phenols are the compound which proves to enhance the body's immune system there by inhibiting the development of new blood vessels (angiogenesis) that is necessary for tumor growth. The present study proved that bark extracts of Buchanania lanzan Spreng had higher content of phenols and flavanoids into it and hence it can be a potent anti-cancerous herbal drug in future.

Keywords: Buchanania lanzan, anticancer, HPLC, phenols, flavonoids, quercetin, galic acid

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