Research Articles

2017  |  Vol: 2(4)  |  Issue: 4 (July- August)
An in vitro antimicrobial evaluation of Cobalt (II) complexes of Amoxicillin, Ciprofloxacin, Norfloxacin and Ketoconazole

Nworie Felix S1., Chukwu Josephine1, Igwe Nkama Oji1

1Department of Industrial Chemistry, Ebonyi State University, Abakaliki

Corresponding author

Nworie Felix S.

Department of Industrial Chemistry, Ebonyi State University, Abakaliki

 

Abstract

Objective: The objective of the present study was to evaluate in vitro antimicrobial properties of cobalt (II) complexes of amoxicillin, ciprofloxacin, norfloxacin and ketoconazole. Materials and methods: The ultra violet - visible absorption spectra and  fourier transform infrared specta of the ligand and the complexes were obtained and helped to elucidate the bonding and antimicrobial properties. The ligands and their complexes were subjected to antimicrobial screening against common bacterial strains E. coli, Staphylococcus aureus, Salmonella typhae, candida and Vibro. Results: The results showed that the complexes are more effective as antibacterial agents as compared to the uncomplexed ligand (control) in all the range of concentrations used. The FTIR data indicated complexation of cobalt(II) ion  to the ligands as shown by the shift of vibration spectra at C=N and C=O and appearance of new bands indicating M-O and M-N bands.  Conclusion: Based on the outcome of this study, it is recommended that cobalt(II) complexes of ciprofloxacin, amoxicillin, ketoconazole and norfloxacin should be used in the treatment of infections caused by these micro-organisms.

Keywords: Cobalt(II) ions, micro-organisms, minimum inhibitory concentration, antimicrobial agent

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