Research Articles

2019  |  Vol: 4(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2019.4.4.4
Phytochemical and pharmacological evaluation of Sarcostemma acidium methanolic extract for anti-acne and thrombolytic activities

Ravi Kant Vishwakarma*, Ajay Yadav, Alok Pal Jain

RKDF College of Pharmacy, Bhopal (M.P.), India

*Address for Corresponding Author

Ravi Kant Vishwakarma

Department of Pharmaceutical Science, SRK University, Bhopal (M.P.), India

Abstract

Objective: The objective of present research work was the investigation of anti-acne and thrombolytic activity of Sarcostemma acidium methanolic extract. Material and methods: Anti-acne and thrombolytic activity of Sarcostemma acidium methanolic extract were determined using P. acne strain and human blood. Results: The methanolic extract of Sarcostemma acidium was found potential anti-acne and thrombolytic activity. Under the investigation of anti-thrombolytic activity at 5 mg/ml concentration of aerial part, extract of Sarcostemma acidium showed 16.2 % clot lysis activity which was highly significant as compared with standard drug 41.32% and 23.19%, respectively. Under the investigation of anti-acne activity, methanolic extract of Sarcostemma acidium against P. acnes was 10±1.70 and 11±1.31. The zone of inhibition for standard drug measured 15±1.67 mm, respectively. Conclusion: The results of investigation of anti-thrombolytic and anti-acne activities confirmed that the herbal extract containing bioactive compounds could be used for the treatment of thrombolytic and acne disease.

Keywords: Herbal extracts, thrombolytic and anti-acne activity

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