Nayna Anandrao Arsod1, 2, Prashant Nandkumar Amale1, Madhuri A Channawar1
1Department of Pharmaceutics, P. Wadhwani College of Pharmacy, Yavatmal (445001).
2Department of Pharmaceutics, Kamla Nehru College of Pharmacy, Butibori, Nagpur (441108).
Ms. Nayna Anandrao Arsod
Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 India (M.S).
Phone No. 9730799868
Objective: Hypertension is one of the largest deaths causing disease for the mankind. Since it is a chronic disease it necessitates long term treatment. Transdermal drug administration generally refers to topical application of agents to healthy intact skin either for localized treatment of tissues underlying the skin or for systemic therapy. The purpose of this research was to develop a matrix-type transdermal therapeutic system containing Diltiazem HCL with different ratios of hydrophilic and hydrophobic polymeric systems. Materials and methods: The ingredients of transdermal patch were Diltiazem HCL, HPMC and Ethyl cellulose. Solvents like Ethanol, Chloroform and Methanol were used throughout the study. After the pre-formulation study drug loaded matrix type transdermal films of Diltiazem HCL were prepared by solvent evaporation method and evaluated for various physicochemical characteristics. In-vitro permeation studies of formulations were performed by using Franz diffusion cells and dialysis membrane was used as barrier membrane. Results and conclusion: Formulation prepared with polymer HPME E15 and ethyl cellulose by using PEG 400 as a plasticizer showed best in vitro skin permeation through Dialysis membrane as compared to all other formulations. The Cumulative drug release from formulation F8 was found to be 98.93% after 8 hrs. Therefore, Diltiazem HCL patch may be a potential formulation for the management of patients with hypertension as a long term release formulation in transdermal drug delivery system.
Keywords: Diltiazem HCL, Transdermal Film, Solvent evaporation technique, In-vitro permeation study