Research Articles

2019  |  Vol: 4(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2019.4.4.3
Formulation, optimization and evaluation of buccal films of Diclofenac Sodium

S. K. Mishra1*, Monika2, P. Bhardwaj 3, R. Singh4, Ajay Kumar Shukla1

1Department of Pharmaceutical Science, ITM College of Pharmacy, Gida Gorakhpur, India

2Laureate College of Pharmacy, Jwalamukhi, H.P., India

3Bundelkhand University, Jhansi, U.P., India

4Shobhit University, Gangoh, Saharanpur, U.P. India

*Address for Corresponding Authors

S. K. Mishra

Department of Pharmaceutical Science, ITM College of Pharmacy, Gida Gorakhpur, India

 

Abstract

Objective: Aim of present study was formulation, optimization and evaluation of buccal films of Diclofenac Sodium. Material and methods: Different formulations of diclofenac sodium were statistically optimized by Taguchi method and prepared individually. Four different formulations were prepared by using HPMC as polymer and PEG-200 as a plasticizer. Formulations were prepared and evaluated for different parameters like weight variation, surface pH, swelling index, folding endurance, drug content uniformity. Results: In-vitro permeation study. Physical parameters of different formulations were evaluated.  Data showed that formulation F2 has less weight variation as compared to other formulations. The surface pH of all formulation films were found 6.5-7.0. Patches of F2 formulation showed higher percentage radial swelling as compared to other formulations. The folding endurance of formulations F1, F2, F3, F4 are found 88, 72, 56 & 64 respectively. The calibration curve of diclofenac sodium was obtained in pH 6.8 phosphate buffer solution. λmax was determined at 279.8 nm with a UV-VIS spectrophotometer. Drug content uniformity of different formulations e.g. F1, F2, F3, F4 were found out to be 26.85, 31.26, 33.25, 33.58 respectively. In-vitro permeation study of F1, F2, F3, F4 formulations have percentage permeation of 42.6%, 37.22%, 34.17%, and 33.92% respectively after 75min. Conclusion: The buccal films prepared with PEG-200 and HPMC can be used for the quick release of drug and so fast action, whereas HPMC films can be used for the sustained release of the drug.

Keywords: Diclofenac sodium, taguchi method, patches, PEG-200, buccal films

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