Review Articles

2019  |  Vol: 4(6)  |  Issue: 6 (November-December) | https://doi.org/10.31024/apj.2019.4.6.3
Role of hyaluronic acid based hydrogel in management of wound healing effect

Kiran Baviskar1, Tanvir Shaikh1, Kiran D. Patil1, Rahul Baviskar2, Santram Lodhi3*

1Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharshtra, India

2Rural institute of Ayurveda & Research Centre hospital, Myani, (M.S.)

3Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Bhopal, (M.P.), India

*Address for Corresponding Author

Dr. Santram Lodhi

Sri Sathya Sai Institute of Pharmaceutical Sciences, RKDF University, Bhopal, (M.P.), India

 

Abstract

Hyaluronic acid (HA) is a natural polymer of the body capable of reaching high molecular weights leading to a excess of properties. HA is a high molecular weight biopolysaccharides, it is a natural linear dipolysaccharides consists of β-(1,4)-linked D-glucuronic acid and β-(1,3) N-acetyl-D-glucosamine units. HA is naturally degraded by hyaluronidases, reactive oxygen species, and by endothelial cells of the lymphatic vessels. HA plays an important role in regulating cell differentiation, migration, angiogenesis and inflammation responses. HA has been widely researched and applied in dermatology. It has shown to be effective as dermal fillers, anti-wrinkle agents, and in tissue regeneration. Serving as volumetric fillers, HA can treat superficial depressions thus improving skin quality. Hydrogels have several unique characteristic properties, including their similarity to tissue extracellular matrix (ECM), support for cell proliferation and migration, controlled release of drugs or growth factors, minimal mechanical irritation to surrounding tissue, and nutrient diffusion, that support the viability and proliferation of cells. Since HA is rich in carboxyl and hydroxyl groups, it can form a hydrogel under mild conditions like chemical modification, crosslinking or photo-crosslinking. HA’s utilization in wound healing is an extremely intriguing area of research for the future. Most notably, HA is an effective alternative to mainstay treatment since it is a natural polymer of the body, thus having limited adverse reactions. Hyaluronic acid is a promising candidate for the tissue engineering field because of its unique physicochemical and biological properties. Thus, this review provides compilation of selective studies have been investigated to develop biocompatibility of hyaluronic acid based hydrogel for effective wound healing applications.

Keywords: Hyaluronic acid, hydrogel, wound healing, dermatology, drug delivery

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