Research Articles

2020  |  Vol: 5(1)  |  Issue: 1 (January-February) | https://doi.org/10.31024/apj.2020.5.1.1
Evaluation of the anti-diabetic potentials of Albiza zygia (DC.) stem barks in alloxan-induced diabetic rats

J. O. Okafoanyali1*, P. A. Akah2, M. A. Omoirri2, O. Onyekwere3, C. Odiaka1

1Biotechnology Research Centre, Nnamdi Azikiwe University, Awka, Anambra State

2Department of Pharmacology and Toxicology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

3National Biotechnology Development Agency, Abuja, Nigeria

*Address for Corresponding Author

Ogochukwu James Okafoanyali

Biotechnology Research Centre, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

 

Abstract

Background: To date, there is paucity of data on the antidiabetic potentials of Albiza zygia. Though it has been reported to possess antidiabetic properties and is used locally in the management of diabetes. Objective: In view of this knowledge gap, the present study assessed the methanolic stem bark extract of Albiza zygia to evaluate its antidiabetic potentials in rat models. Materials and Methods: Methanolic extract of Albizia zygia (stem bark) was prepared by cold maceration for 48 hours and the crude extract was fractionated to obtain n-hexane, n-butanol and diethylether soluble fractions (HF, BF and DF) respectively. The crude extract and its fractions were screened to unveil the resident phytochemical constituents. The fractions (HF, BF and DF) and methanol extract were tested for antidiabetic effect on alloxan monohydrate induced diabetic rats. Results and conclusion: The results revealed the presence of alkaloid, tannin, saponin, flavonoid, terpenoids, cardiac glycoside, carbohydrate and reducing sugars in the extract while the oral LD50 was above 5000 mg/kg. The methanol extract was significantly (P<0.05) reduced the blood glucose level of diabetic rats in a dose dependent manner after 22 days treatment. The fractions at 800 mg/kg were significantly (P<0.05) reduced blood glucose after 6 hours. The potency of the fraction in reducing the blood glucose was in the order BF > HF > DF. The effect of the extract on the lipid profile, liver and kidney function of the diabetic rats was investigated. The extract was significantly (P<0.05) reduce the serum LDL, triglyceride and total cholesterol concentration and a significant (p < 0.05) increase in the serum HDL concentration. The serum AST, ALP and ALT concentration was significantly (P<0.05) reduced in all the groups. The dose of 800 mg/kg treated group was significantly (P>0.05) reduced the Urea and Creatinine concentration. Thus, the study lends support to the ethnomedicinal use of the plant in the management of diabetes.

Keywords: Diabetes mellitus, hyperglycemia, Albizia zygia, alloxan monohydrate

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