Parigala Madhavi, B. L. Kudagi*, Madhavulu Buchineni, Rama Mohan Pathapati
Post graduate, Head of the department, Professors
Department of Pharmacology, Narayana Medical College, Nellore, Andhrapradesh, India.
*Address for Corresponding author
Dr. B. L. Kudagi,
HOD, Department of Pharmacology,
Narayana Medical College, Nellore, Andhrapradesh, India, 524003
Objectives: To evaluate antidepressant activity of aqueous extract of Prosopis cineraria leaves by using Tail suspension test in Swiss albino mice. Materials and Methods: 24 Swiss albino mice of 6-8wks old weighing in the range of 20 to 25gms were selected for the study and administered the drugs, viz Control- normal saline( 2ml/kg) oral , Standard- amitriptyline (10mg/kg) oral, and Test drug Prosopis cineraria (100 & 200mg/kg) oral . All the drugs were administered , screened for antidepressant activity at 0, 20, 60, 90 min by suspending them from a rod 50cm above the ground level and duration of immobility time was recorded over a period of six minutes (discarding initial two minutes to avoid bias). Results: Prosopis cineraria at 100 & 200 mg/kg has shown significant antidepressant activity with decrease in duration of immobility with 97.00 ± 2.30 & 94 ± 3.23 sec at 90min with a p value of <0.0001 respectively. Conclusion: In our study, we identified the potent and efficacious antidepressant activity of aqueous extract of leaves of Prosopis cineraria.
Keywords: Antidepressant, Prosopis cineraria, Tail suspension test