Research Articles

2020  |  Vol: 5(3)  |  Issue: 3 (May- June) | https://doi.org/10.31024/apj.2020.5.3.6
Investigations on Citrullus colocynthis seeds for aphrodisiac activity in male albino rats

Shain Kumar Singh, Alok Pal Jain*, Manisha Tandon

RKDF College of Pharmacy, SRK University, Hoshangabad Road, Misrod, Bhopal - 462026 (MP) India

*Address for Corresponding Author

Dr. Alok Pal Jain

RKDF College of Pharmacy, SRK University, Hoshangabad Road, Misrod, Bhopal - 462026 (MP) India

 

Abstract

Objective: The aim of the study is to evaluate the effect of the aqueous and ethanolic extract of Citrullus colocynthis on reproductive abilities of male albino rats. Materials and methods: Plant extracts at doses of 200 and 400 mg/kg body weight were administrated for 21 days. Activity was observed by assessment of counting number of mounts, mating performance, hormonal analysis, testes-body ratio and sperm count. Results: The ethanolic extract of Citrullus colocynthis L. seeds at higher concentration (400 mg/kg body weight) showed significant aphrodisiac activity on male wistar albino rats as evidenced by an increase in number of mounts, mating performance, hormonal analysis, testes-body ratio and sperm count. On the other hand, ethanolic extract at lower dose (200 mg/kg. body weight) and aqueous extract (400 mg/kg body weight) showed moderate aphrodisiac property. The extract was also observed to be devoid of any adverse effects and showed negative results for acute toxicity. Conclusion: Thus, the results of the present study demonstrate that ethanolic extract of C. colocynthis seeds enhance sexual behavior in male rats.

Keywords: Citrullus colocynthis; Seeds; Aphrodisiac; Mating; Herbal medicine, Male Rat, sexual behavior

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