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Amit Jharia1, 2, Saurabh Pagare1, 4*, Asha Khanna1, 2, Manila Bhatia3, Varsha Aglawe2, Mubashir Azam Mir2
1AVIKA Biological Science Research Foundation, Jabalpur (M.P.) India
2Department of Zoology and Biotechnology, Govt. Science College, Jabalpur (M.P.) India
3Department of Zoology and Biotechnology, Govt. M. H. College of Home Science & Science for Women, Jabalpur (M.P.) India
4Department of Botany and Biotechnology, Sarojini Naidu Govt. Girls P.G. College, Bhopal (M.P.) India
*Address for Corresponding Author
Dr. Saurabh Pagare
Department of Botany and Biotechnology, Sarojini Naidu Govt. Girls P.G. College, Bhopal (M.P.) India
Abstract
Objective: Artemether is a common anti-malarial drug used in combination with Lumefantrine for the treatment of uncomplicated falciparum malaria. It is also reported to be used as anti-cancer drug; hence it was thought worthwhile to explore its anti-mitotic effects on the onion root tip system. Material and methods: Onion bulbs were grown in tap water where they sprouted 2-3 mm roots. Their mitotic index reading at 0hour was noted then they were transferred to the test solutions.The plasma concentration of the drug is reported to be 184ng/ml; so for testing its effect the drug was added to the water in which onion tips were grown with 92ng/ml (½ plasma concentration), 184 ng/ml (plasma concentration) and 368ng/ml (2×plasma concentration). Results and conclusion: Readings of % mitotic index (MI) were noted at 0 hr and 24& 48hr after putting the onions in the experimental solutions. It was found that there was depression of the MI% at all the three concentrations when compared to their respective 0hr readings and most of the time the depressions were statistically significant.Regarding the effect of curcumin, it was found that at a concentration of0. 33% and 0.66% curcumin induces MI% depression after 24 & 48hr, but at 1.1%, the depression is less and actually there is a slight increase. Thus it acts as both anti-mitotic and an immunomodulator.
Keywords: Artemether, curcumin, onion root tip, mitotic index
