Gopal Rai1, Pramod Maurya1, Pushpendra Kumar Jain2, Ajay Kumar Shukla1
1Department of Pharmaceutical Science, Guru Ram Das Khalsa Institute of Science & Technology Pharmacy, Jabalpur (M. P.), India
2IIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India
Objective: Objective of this work was to evaluate the in vitro anthelmintic and H + -K + ATPase inhibitory possible of Hydroalcohalic (70:30) extract of Achyranthes aspera Linn. aerial part. Materials and Methods: The total flavonoid content, phenol content, anthelmintic activity, H + -K + ATPase inhibition assay was performed in presence of different concentrations of Hydroalcohalic (70:30) extract. Results: The Hydroalcohalic (70:30) extract of Achyranthes aspera Linn showed considerable (*P < 0.05) anthelmintic and proton pump inhibitory activity in the goat gastric mucosal homogenate which was equivalent to standard. Conclusions: The activities were found to be dose dependent and this study indicates that Hydroalcohalic (70:30) extract of Achyranthes aspera were found to suppress sheep mucosal H+K+ ATPase activity in-vitro. So, further study is needed to confirm the gastro protective property of Achyranthes aspera aerial part.
Keywords: Achyranthes aspera Linn, H+ K+ ATPase inhibition, anthelmintic, Folin-Ciocalteau, Albendazole