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Pallavi Chaudhari1*, Somnath Kedar1, Shilpa Chaudhari1
1Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044
*Corresponding Author
Dr. (Mrs.) Pallavi Chaudhari
Department of Pharmaceutics,
Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044
Abstract
Objective: An attempt was to formulate fast dissolving tablet of Diltiazem HCl by using different synthetic superdisintegrants. Material and methods: The formulations were analyzed using Differential Scanning Calorimetry, FTIR spectroscopy. Results and conclusion: In all cases it was observed that as the concentration of superdisintegrants increased there was less disintegration time and more dissolution. Indion 414 formulation showed less disintegration time and more dissolution rate while other formulations showed more disintegration time and less dissolution rate, compared to Indion 414.
Keywords: Fast dissolving tablet, superdisintegrants, Indion 414
