George Zhu1, Fabio Musumeci2, Peter Byrne2, Deepti Gupta3, Ekta Gupta4
1The Institute of Oncology, Tehran University of Medical Sciences, Tehran
2Sacoor Medical Group, London, United Kingdom.
3International Centre for genetic Engineering and biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
4Institute of liver and biliary sciences, sector D1 vasant kunj, New Delhi, India
*Address for correspondence
Prof. George Zhu
The Institute of Oncology, Tehran University of Medical Sciences, Tehran
Objective: The global burden of hepatocellular carcinoma (HCC) is significant. In search for the effective approach of PHC, the objective of present study was to investigate in detail the objective response of the combined protocol of chemotherapy and traditional medicine in the treatment of hepatocellular carcinoma (HCC). Methods: All ten patients with HCC were in progressive at hospitalization. The criteria of complete remission (CR) and/or partial remission (PR) is according to the rules where physician have in common with in clinics. Results: Three of ten HCCs (two patients with liver CT tumor 6.3 x 4.5, 11.1 x 6.2, respectively) obtained complete remission using combination chemotherapy and traditional medicine. Three patient HCCs (one patient with AFP 7500 ng/ml) obtained complete remission through only 5-Flourouracil and traditional medicine. Two HCCs (one patient with AFP 200ng/ml, ascites +++, icterus index 100u) obtained complete remission through cantharidine and traditional medicine. The main protocol of traditional medicine with adjuvant the antibiotics regimen and small dosage of dexamethasone (prednisone) administration was given in a primary hepatocellular carcinoma (AFP +, ascites +++, Jaundice +++, liver tumor 3.2 x 3.0). One acute promyelocytic leukemia complicated with metastatic hepatocellular carcinoma (7.0 x 4.5cm) was in CR with all-trans retinoic acid (ATRA) and traditional medicine. All ten patients with disease-free survival were 2,2,8,6,10,15,20,20 years, 18 months (died in HCC relapse), and 20 months (died in leukemia relapse) respectively. Conclusion: In this study, traditional herbal medicine had been successfully conducted in treatment of ten advanced hepatocellular carcinomas. Interesting, one case was only given all-trans retinoic acid (ATRA) and traditional medicine. A hepatitis B virus (HBV) integration in a human steroid hap retinoic acid receptor (RARβ) previously detected may involve in hepatocellular carcinogenesis, and ATRA use in this case. And also, an additional data indicate that human hepatocyte growth factor (HGF) and oncogenic HGF receptor (HGFR/met oncogenic receptor) act as a trigger for liver regeneration after partial hepatectomy and liver injury, even in (hepatocellular) carcinogenesis, which was also discussed.
Keywords: HCC, HBV, HCV, HGF/met, oncogenic receptor, 5-flourouracil traditional herbal medicine