Research Articles

2020  |  Vol: 5(4)  |  Issue: 4 (July- August) | https://doi.org/10.31024/apj.2020.5.4.4
Fabrication and characterization of floating microspheres of Dexrabeprazole Sodium to improve bioavailability

Krishna Kumar Kashyap *, Anjana Bharadwaj

RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India

*Address for Corresponding Author

Krishna Kumar Kashyap

RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India

 

Abstract

Objective: Aim of present study was to develop floating drug delivery system (FDDS) to prolong the residence time of the dosage form within the GI tract. Material and methods: Floating microspheres containing dexrabeprazole were prepared by emulsion solvent diffusion technique using various proportions of drug and polymer, such as Ethyl cellulose and Hydroxypropylmethylcellulose (HPMC). The drug to polymer ratio used to prepare the different formulations was 1:7. The prepared floating microspheres were characterized for shape and surface morphology, size, percent drug loading and in vitro drug release. Results and conclusion: Formulation F1 showed good results with respect to the various evaluation parameters among various batches (F1-F8). The particle size increased with increase in polymer concentration. The drug entrapment efficiency was increased with increase in concentration of polymers. In-vitro buoyancy and the in vitro drug release decreased with respect to increase in concentration of polymers. The developed system has the dual advantages of being gastro-retentive, to increase oral bioavailability and releasing drug in a controlled manner.

Keywords: Floating drug delivery systems, gastric residence time, microsphere, dexrabeprazole, formulation

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