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Varsha Karan Patnaik*, Anjana Bharadwaj
RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India
*Address for Corresponding Author
Varsha Karan Patnaik
RKDF College of Pharmacy, SRK University, Hoshangabad road, Misrod, Bhopal - 462026 (MP) India
Abstract
Objective: Objective of present work was to develop and characterizes chitosan based in-situ gelling system for delivery of Amphotericin B. Material and methods: The chitosan based in situ gel was developed in which liposomal Amphotericin B was incorporated. Results and conclusion: The evaluation showed that in comparison to pure drug incorporated in situ gel, the liposomal Amphotericin B incorporated in situ gel was more effectively forming gel and the gelation time was also quick. The best formulation among liposomal Amphotericin B incorporated in situ gel was G2 which gel formed at 36oC and the gelation time of G2 formulation was found to be quicker than the rest of the formulations i.e. 41sec. The viscosity was found to be adequate in case of G2 formulation i.e. 877.67cps and 10132.00cps. The In vitro drug release studies showed that the pure Amphotericin B incorporated in situ gel gave less release as compared to the liposomal Amphotericin B incorporated in situ gel.
Keywords: Chitosan based in situ gel, liposome, microsphere, amphotericin B
