Review Articles

2020  |  Vol: 5(2)  |  Issue: 2(March-April) | https://doi.org/10.31024/apj.2020.5.2.1
Versatility of nanosuspension formulation in various drug delivery systems: A brief review

Pradeep1, Kamal2, Beena Kumari1*

Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, Haryana, India-123401

*Address for Corresponding Author:

Beena Kumari

Assistant Professor

Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, Haryana, India-123401

 

Abstract        

Nano suspension formulations are attractive, encouraging and consist purely poor water soluble drugs without any matrix material. Nano suspension technology solved the problem of poorly aqueous soluble and less bioavailability is also overcome by using this technology.  Nanosuspension formulation is applicable to all aqueous insoluble drugs. The objective behind this study is to review the work done on nanosuspensions and recent drugs used to formulate this dosage form with their uses. The formulation of nanosuspensions include  drugs, stabilizers,  organic  solvents  and  other  additives  such  as  buffers,  salts,  polyols,  osmogents  and cryoprotectant.  Nanosuspension formulations are synthesized by using wet mill, high-pressure homogenizer, emulsion-solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspensions   can be administered by oral, parenteral, pulmonary and ocular routes. It can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels. This review article describes the nanosuspensions, their preparation methods, characterization, and recent applications of the nanosuspension.

Keywords: Nanosuspension, solubility, solvent evaporation, recent applications

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