Qin Zhang1, George Zhu2*
1Department of Medicine, Zhenjiang radio factory, Zhenjiang, China
2The Institute of Oncology, Tehran University of Medical Sciences, Tehran
The Institute of Oncology, Tehran University of Medical Sciences, Tehran
Objective: To study effect of Cantharidin which was contained in Mylabris phalerata or M. cichoris L. in China or Cantharis vesicatoria in European, one kind of toxic insect, on different types of cancer patients. Methods: In this study, using comparative analyses, 6 of 7 cancers patient having malignant "nest" cells appears to be pathologically degenerated and necrosis occurs in diverse degree after undergoing demethylcantharidin. Demethylcantharidin 12-16mg added in 5% glucose or GNS solution and given intravenous daily, 2-8 weeks/one course. Cantharidin was treated over three weeks in 4 patients (total dosage over 300mg), cantharidin up to 15 days in 1 case (total dosage 210mg), and cantharidin within 10 days (total dosage 100mg) in 2 cases. Histologically and laparotomy were performed in 7 patients after 1 to 3 days of cantharidin. The pathological changes were measured by score analysis. Results and conclusion: The object response was proportion to the dosage of cantharidin. Moreover, there was coexistence of degeneration and coagulative necrosis of malignant "nest" cells, the phenomenon of lymphocyte infiltration and fibrosis around "nest" cells. In vitro cantharidin was remarkably sensitive to the inhibition of DNA, RNA synthesis, stimulate lysozyme activity in PHC cell line and xenograft tumors. The findings implicate that cantharidin is clinical therapeutically benefits.
Keyword: Cancer, hepatocellular carcinoma, Cantharidin, pathological changes